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We report observations of crystal defect induced modifications in the laser-excited Er3+ photoluminescence spectra of single-crystal Er2O3 thin films. These include marked enhancement of transition intensities known to be weak or nonexistent in as-grown samples. In this Letter, we examine the temperature and defect density dependence of the measurements and suggest photophysical processes that may account for these unexpected results. 

Few techniques are available for studying the nature of forces that drive subcellular dynamics. Here we develop two complementary ones. The first is femtosecond stereotactic laser ablation, which rapidly creates complex cuts of subcellular structures and enables precise dissection of when, where and in what direction forces are generated. The second is an assessment of subcellular fluid flows by comparison of direct flow measurements using microinjected fluorescent nanodiamonds with large-scale fluid-structure simulations of different force transduction models. We apply these techniques to study spindle and centrosome positioning in early Caenorhabditis elegans embryos and to probe the contributions of microtubule pushing, cytoplasmic pulling and cortical pulling upon centrosomal microtubules. Based on our results, we construct a biophysical model to explain the dynamics of centrosomes. We demonstrate that cortical pulling forces provide a general explanation for many behaviours mediated by centrosomes, including pronuclear migration and centration, rotation, metaphase spindle positioning, asymmetric spindle elongation and spindle oscillations. This work establishes methodologies for disentangling the forces responsible for cell biological phenomena. 

Audio-visual representation learning aims to develop systems with human-like perception by utilizing correlation between auditory and visual information. However, current models often focus on a limited set of tasks, and generalization abilities of learned representations are unclear. To this end, we propose the AV-SUPERB benchmark that enables general-purpose evaluation of unimodal audio/visual and bimodal fusion representations on 7 datasets covering 5 audio-visual tasks in speech and audio processing. We evaluate 5 recent self-supervised models and show that none of these models generalize to all tasks, emphasizing the need for future study on improving universal model performance. In addition, we show that representations may be improved with intermediate-task fine-tuning and audio event classification with AudioSet serves as a strong intermediate task. We release our benchmark with evaluation code and a model submission platform to encourage further research in audio-visual learning. 

Abstract Gamma-ray binaries are luminous in gamma rays, composed of a compact object orbiting a massive companion star. The interaction between these two objects can drive relativistic outflows, either jets or winds, in which particles can be accelerated to energies reaching hundreds of teraelectronvolts (TeV). However, it is still debated where and under which physical conditions particles are accelerated in these objects and ultimately whether protons can be accelerated up to PeV energies. Among the well-known gamma-ray binaries, LS 5039 is a high-mass X-ray binary with an orbital period of 3.9 days that has been observed up to TeV energies by the High Energy Stereoscopic System. We present new observations of LS 5039 obtained with the High Altitude Water Cherenkov (HAWC) observatory. Our data reveal that the gamma-ray spectrum of LS 5039 extends up to 200 TeV with no apparent spectral cutoff. Furthermore, we confirm, with a confidence level of 4.7σ, that the emission between 2 and 118 TeV is modulated by the orbital motion of the system, and find a 2.2σhint of variability above 100 TeV. This indicates that these photons are likely produced within or near the binary orbit, where they can undergo absorption by the stellar photons. In a leptonic scenario, the highest energy photons detected by HAWC can be emitted by ∼200 TeV electrons inverse Compton scattering stellar photons, which would require an extremely efficient acceleration mechanism operating within LS 5039. Alternatively, a hadronic scenario could explain the data through proton–proton or proton–gamma collisions of protons accelerated to petaelectronvolt energies.